Global Disease Lead, PNH

At Alexion, AstraZeneca Rare Disease, we are innovators, leaders, and collaborators. At the heart of everything we do is an intense desire to pursue the toughest challenges and truly change the world for people living with rare and devastating diseases.

 

Alexion’s Global Marketing and Market Access team (GMMA) is an integrated strategy and operations team, with the core objective to develop disease and brand commercial and access strategies, as well as global marketing materials and negotiation strategies, while working closely with markets for implementation. The team diligently monitors the performance of the business and the effectiveness of our strategies, helping to position our brands for sustained long-term access and success. Additionally, the GMMA team delivers commercial strategies for our pipeline programs and establishes commercial marketing and access strategies for new product launches. Our unique culture thrives on collaboration, authenticity, creativity, and pushing boundaries in all that we do to advance patient care.

 

The Global Brand Strategy Lead, Hematology is a foundation role for the success of the PNH company strategy focus on Top 7 countries.  You are accountable for leading the development and profitable management of your respective indication with full accountability for commercialization.  You have a leadership role within a matrix working model between global and local markets and across functions.  Working in complex and competitive markets, you are accountable for creating a collaborative and high-performance environment that supports the innovation required to identify and realize substantial value opportunities.

 

 

Key Responsibilities:

 

Brand Strategy In-Line Products: 

 

• You are responsible for the VST, Lead of Value Subteam in which you will refine and safeguarde strategic value propositions based on market events and clinical outcomes. In collaboration with Medical and Market Access teams to develop proposals and business cases for further data generation and RWE.
• You lead the DSP, Disease Strategy Plan development and roll-out. Provide input into strategic planning process (patient funnel, buying process, patient segmentation..etc).
• Prioritize the key programs coming out of the DSP and lead project workstreams. Lead the planning meetings with key stakeholders.
• You are accountable for ensuring CRT (Competitor response team) is led  cross-functionaly by you.
• You are part of the GPT Core Team member, keeping the GPT apprised of key programs and workstreams. As well as collaborate and align with key functions and government bodies ie Regional Area Heads (US, INTL, JP), GPT, GST, Clinical, Development, Regulatory, SciComms, Training etc
• You provide regular update on strategy and global performance to senior leadership, ie GCOLT.

 

Launch Strategy

 

• You are accountable for driving the Global Pre-Launch strategy and planning 12-18 months prior to launch. Provide commercial input into development programs.
• Partnering with (R&D, Operations, Corporate Affairs, Finance, et al) and regional/local teams to develop relevant launch strategy. And finally work with Regional colleagues to plan the market shaping activities 12-18 months prior to launch.

 

Business & CommercialPerformance:

 

• You are responsible for develop and refine commercial strategy (positioning, messaging, buying process, patient/HCP segmentation …etc.). Partnering with Regional Commercial leads to ensure local execution of strategy.
• You provide regular reports of the development and measurement of LTP global forecasts
• Finally, build the Stakeholder mapping

 

Pipeline:

• It will be required to prepare Business Cases for some assets to be assesed for the Leadership team

 

You will need to have:

• Bachelor's degree in business or life sciences.
• 10+ years in pharmaceutical or biotech industry in roles encompassing strategic pre-launch planning and launch, with global/regional/local experience and thorough understanding of the diverse requirements of Global markets .
• Leadership experience in the pharmaceutical or biotechnology industry with accountability and a proven track record for delivering on business goals in a major healthcare market.
• Broad marketing and commercial experience with demonstrated success across various stages of the brand lifecycle, including pre-launch planning, launch execution, and long-term business planning
• Profound understanding of drug development and commercialization in rare disease
• Solid grasp of ongoing paradigm changes and future trends in healthcare commercialization.
• Demonstrated ability to collaborate across matrix teams and achieve goals by delivering through others.
• Proven experience and knowledge of a broad base of external partners and customers including patients, prescribers, payors, providers and in/out license partners.
• P&L management experience and ability to build a financial Business Cases
• Experienced with key global regulations in the field of pharmaceutical compliance and commercialization, including pharmacovigilance
• Excellent communications skills across a diverse set of stakeholders (commercial, clinical, medical, etc.)
• AI experience integrating tools into cross-functional workflows to improve strategic decision-making, efficiency and business impact
• undefined

 

We would prefer you to have: 

• An advanced degree (MBA, MSc or PhD) is preferred 
• You can think globally, regionally and locally.
• You bring an entrepreneurial spirit and strategic mindset including innovation and critical thinking with performance-oriented drive.
• You can integrate a variety of perspectives into meaningful strategies and programs.
• You embrace curiosity, collaboration and smart risk taking as a prerequisite for joint success.
• You enthusiastically embrace the diversity of individual healthcare ecosystems as significant opportunity.
• You can relate and connect deeply with various healthcare and business markets in order to deliver direction and support.
• You can create and mobilize an inclusive work environment of highest integrity and quality, fostering learning, growth, teamwork, individual development and attraction of top talent.
• You posess excellent communication skills and a strong personal presence internally and externally, acting as a strong catalyst and influencer.

Date Posted

13-oct-2026

Closing Date

28-oct-2026

Alexion is proud to be an Equal Employment Opportunity and Affirmative Action employer. We are committed to fostering a culture of belonging where every single person can belong because of their uniqueness. The Company will not make decisions about employment, training, compensation, promotion, and other terms and conditions of employment based on race, color, religion, creed or lack thereof, sex, sexual orientation, age, ancestry, national origin, ethnicity, citizenship status, marital status, pregnancy, (including childbirth, breastfeeding, or related medical conditions), parental status (including adoption or surrogacy), military status, protected veteran status, disability, medical condition, gender identity or expression, genetic information, mental illness or other characteristics protected by law. Alexion provides reasonable accommodations to meet the needs of candidates and employees. To begin an interactive dialogue with Alexion regarding an accommodation, please contact [email protected]. Alexion participates in E-Verify.