Post-Doctoral Research Fellow - Gene Editing Therapy

Site: Massachusetts Eye and Ear Infirmary

 

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

 

Job Summary

The postdoctoral fellows will function as part of a multi-disciplinary team of scientists and clinicians. Responsibilities include participating in all aspects of data acquisition and management; developing, modifying, and executing analytical protocols; preparing publications and scientific presentations; disseminating results in peer-reviewed scientific journals and at major national and international meetings, and mentoring junior staff. Opportunities exist for excellent scientific interactions and collaborations with an extensive program of seminars, symposia, and other meetings focused on a large array of topics in clinical research and related technology.

 

We are seeking postdoctoral fellows to work on gene and editing therapy for genetic hearing loss and advancing our findings toward clinical applications. Our gene and editing therapies have successfully restored hearing in multiple mouse models (Gao et al., Nature, 2017; Du et al., Mol Ther, 2023; Yong et al., Nat Commun, 2023; Zhu et al., Sci Transl Med, 2024; Wei et al., JCI, 2025). The projects include the development of new technologies (e.g. RNA editing, epigenetic modifications, shRNA) for different forms of genetic hearing loss and multiple IND-enabling studies for gene and editing therapies with the goals to initiate clinical trials in 3 years. The work is supported by the NIH SCGE program (https://scge.mcw.edu/ind-enabling-studies-multiple-disease-platforms/).

Our laboratory employs state-of-the-art technologies, including in vitro adult cochlea explant culture, reprogramming, scRNAseq, inner ear organoids, genome editing, gene therapy, viral and non-viral delivery, and physiological function analysis. We are collaborating with the industry, working with CROs and interacting with the FDA to bring our work towards the clinic.

We are pioneers in clinical translational applications, having conducted the first successful OTOF gene therapy trial in children born with complete hearing loss, resulting in restored hearing and speech capabilities (Lv et al., The Lancet, 2024; Wang et al., Nat Med, 2024).

Our lab is part of Eaton-Peabody Laboratories, the largest hearing research center globally, renowned for its diverse research programs in hearing science. We offer a unique and exciting opportunity for candidates interested in advancing basic research to translational applications, including human studies.

Candidate Requirements: We seek individuals with a Ph.D., M.D./Ph.D., or M.D. For gene/editing therapy, we seek candidates with a strong background in genetic hearing loss, in vivo animal inner ear study, AAV-mediated gene therapy and editing technology. A strong track record of scientific publications is essential.

Salary: $71,750.00 - $73,544.00/Annual

 

 

Onsite

 

243-245 Charles Street

 

40

 

Regular

 

Day (United States of America)

 

5110 Massachusetts Eye and Ear Infirmary is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

 

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