Research Associate/Senior Research Associate - Peptide/High Potent APIs (HPAPI)/Organic/Antibody Drug Conjugation (ADC)

Peptide Chemist:

• Plan and execute solid-phase and solution-phase peptide synthesis (SPPS/LPPS) using automated synthesizers such as Syro and CEM Liberty Blue

• Independently handle peptide synthesis across scales from gram to 1 kg, with troubleshooting abilities

• Purify and characterize peptides using preparative HPLC, analytical HPLC, LC-MS, and MS

• Operate, calibrate, and maintain lab equipment to keep synthesis workflows running smoothly

• Maintain compliance with laboratory safety and SHE (Safety, Health & Environment) standards

• Review relevant literature to inform synthetic strategy and troubleshooting approaches

• Keep accurate, timely experimental records (lab notebooks, batch records, ELN entries as applicable)

High Potent APIs (HPAPI):

• Perform hands-on laboratory chemistry activities involving high-potency APIs / potent compounds.

• Execute chemical reactions, work-ups, purification and related laboratory processes.

• Handle HPAPIs in accordance with applicable safety, containment and handling procedures.

• Maintain accurate laboratory records, experimental data and documentation.

• Support process development, optimization and troubleshooting activities.

• Perform analytical sample preparation and coordinate with analytical teams as required.

• Follow established GMP, EHS and laboratory safety requirements.

• Support investigation and resolution of laboratory/process-related issues.

• Where required, support chemistry activities related to ADC and highly potent payloads.

• Work effectively with cross-functional teams including analytical and other chemistry groups.

Organic Chemist:

• Hands-on experience in performing chemical reactions from mg to gram scale independently under scientific guidance

• Strong knowledge of analytical and purification techniques, including NMR, Mass, HPLC, CombiFlash, and column chromatography

• Skilled in handling reaction setups, glassware assemblies, reagent charging, temperature control, and nitrogen operations

• Excellent documentation and data management practices with the ability to follow scientific procedures, patents, and experimental instructions accurately

Scaleup Chemist:

• Experience in process R&D, scale-up synthesis, and purification from gm to kg scale

• Skilled in handling 50L/100L GLR assemblies and basic technology transfer activities

• Proficient in 1H NMR, HPLC, and LCMS interpretation

• Strong project execution and team collaboration skills

Antibody Drug Conjugation Chemist (ADC)

• Synthesis and purification of complex antibody drug conjugate (ADC) molecules

• Synthesis of different types of linkers – using natural and unnatural amino acids, PEGs

• Synthesis of highly potent drug molecules – payloads

• Purification of complex and large molecules by flash column and HPLC

• Handling various type chemistry with different payloads

• Interpretation and characterisation of higher molecular weight compounds