Senior Scientist

Overview

Waters Corporation is seeking an accomplished scientific leader to oversee antibody and resin production in support of the VICAM® column production value stream. In this critical role, you will collaborate closely with Research & Development, Engineering, and Manufacturing teams to ensure the reliable, on-time production of antibodies and resins that meet quality, capacity, and operational requirements. The successful candidate will drive process excellence, optimize production performance, and ensure a consistent supply of key materials to support customer demand and the ongoing success of the column production line.

 

Responsibilities

Cell Culture Operations

• Retrieve, thaw, and initiate mammalian cell lines from cryogenic storage
• Monitor culture health, morphology, viability, and contamination status
• Perform routine passaging and expansion of cell cultures
• Maintain safety-stock cultures and frozen cell banks
• Perform sterile manipulations within biosafety cabinets

 

Seed Train Expansion

• Expand cultures through multiple vessel scales to generate inoculum
• Evaluate expansion readiness based on growth phase and culture condition
• Perform aseptic transfers, media additions, and feeding activities
• Maintain proper labeling and tracking of cultures

 

Bioreactor Setup & Operation

• Install and prepare single-use cultureware systems
• Perform system pressurization testing and leak checks
• Execute fill, flush, and priming procedures
• Perform bioreactor inoculation activities
• Monitor process parameters including temperature, pH, dissolved oxygen, and gas supply
• Collect in-process samples for routine analysis

 Cryopreservation & Cell Banking

• Harvest cultures for long-term storage
• Prepare freezing suspensions using appropriate cryoprotectants
• Aliquot into cryovials and perform controlled freezing steps
• Maintain cryogenic storage inventory and records 

Documentation & Compliance

• Maintain accurate batch records and laboratory documentation
• Record culture observations, process steps, and test results
• Follow established SOPs and aseptic handling procedures
• Adhere to safety and biosafety requirements 

Qualifications

Education & Qualifications

• Advanced degree in a relevant field — Bachelor Degree in Cell Biology, Molecular Biology, Bioengineering, Biotechnology, or related discipline required, MS preferred.
• Extensive research and development experience in cell culture, cell line development, or bioprocess engineering.
• Industry experience in biologics, cell therapy, or related manufacturing environments.
• Aseptic technique and sterile handling
• Mammalian cell culture fundamentals
• Laboratory safety and biosafety practices
• Basic bioreactor operations
• Microscopy and culture assessment
• Accurate record keeping and documentation
• SAP ERP Systems