- Location
- Philadelphia, PA
- Department
- Novel CAR Design
- Seniority
- Senior
- Experience
- 3+ years
- Education
- PhD
- Source
- Greenhouse
Description
Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma.
Legend Biotech is seeking a Senior Scientist as part of the R&D Leadership Development Program based in Philadelphia, PA.
Role Overview
The Early Career Leadership Program at Legend Biotech is a strategic, enterprise-focused development experience designed to accelerate the growth of high-potential professionals early in their careers. Rooted in our commitment to cultivating enterprise-minded, value-driven leaders, this program provides structured rotational exposure, executive mentorship, and real-time business impact across scientific, operational, and corporate functions.
The R&D Hi-Po Leadership Development Program is a project-based, enterprise leadership accelerator designed for high-potential PhD graduates who aspire to shape the future of cell and gene therapy. Over 2.5–3 years, participants will lead 3-4 high-impact, 8-12-month strategic projects across R&D, Preclinical Development, Technical Development, Business Development and Regulatory Affairs.
This immersive experience is built to cultivate scientific leaders capable of translating discoveries into development, advancing complex pipeline programs, and influencing cross-functional strategy. Participants will gain enterprise exposure, executive mentorship, and access to a formal Annual Leadership Development Series focused on strategic thinking, regulatory and clinical acumen, and senior leadership readiness. Join us in advancing the frontiers of cell and gene therapy—where your discoveries can redefine treatment paradigms and transform patient outcomes worldwide
We are seeking a highly motivated Senior Scientist to join our growing In Vivo CAR-T Cell Therapy team. The successful candidate will contribute to the development of our in vivo CAR-T platform and pipeline by leveraging expertise in cellular immunotherapy, virology, and immunology. This role requires scientific excellence, strong collaboration skills, and the ability to drive projects in a fast-paced environment.
Join us in redefining what’s possible and build a career where your growth and patient impact go hand in hand.
Key Responsibilities
- Design and execute research projects to drive innovation of cell and gene therapy platforms and advance pipeline development.
- Develop and optimize assays, including but not limited to lentiviral vector production and titration, advanced multi-parameter flow cytometry, Incucyte, ELISA, cytotoxicity assays, and PCR-based analyses.
- Conduct in vitro and in vivo studies to evaluate potency, function, and safety of drug candidates.
- Collaborate closely with cross-functional teams to evaluate novel designs and generate robust, reproducible, and data-driven conclusions.
- Analyze, interpret, and document experimental results in a timely and highly organized manner, maintaining accurate scientific records and ensuring data integrity.
- Contribute to scientific strategy, experimental planning, and technology innovation to support pipeline advancement.
Requirements
- PhD in Immunology or a related discipline.
- Minimum of 3 years of experience in cell and gene therapy research, with experience in CAR-T cell therapy strongly preferred.
- Strong hands-on experience with cellular immunology, viral vector technologies, and functional assay development.
- Demonstrated scientific productivity through publications, patents, or equivalent achievements.
- Strong experimental design, data analysis, troubleshooting, and problem-solving skills.
- Excellent verbal and written communication skills, with the ability to effectively present complex scientific concepts to diverse audiences.
- Passion for advancing next-generation cell and gene therapies.
- Strong sense of scientific ownership, accountability, and attention to detail.
- Commitment to continuous learning and staying current with emerging scientific and industry developments.
- Strong team-oriented mindset with a willingness to mentor and support colleagues.
- Ability to thrive in a dynamic, fast-paced, and highly collaborative environment.
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The base pay range below is what Legend Biotech USA Inc. reasonably expects to offer at the time of posting. Actual compensation may vary based on experience, skills, qualifications, and geographic location. The company reserves the right to modify this range as needed and in accordance with applicable laws.
Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles.
Benefits and Paid Time Off: Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work.
Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
EEO Statement
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.
