Scientist II - LNP Formulation

Scientist II - LNP Formulation ROCGJP00043362

• Hourly pay: $50/hr
• Worksite: Leading biotechnology company (San Diego, CA 92111- Onsite)
• W2 Employment, Group Medical, Dental, Vision, Life, Retirement Savings Program, PSL
• 40 hours/week, 3 Month Assignment

A leading biotechnology company seeks a Scientist II - LNP Formulation to execute and optimize the formulation of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery in a hands-on laboratory role.

Scientist II - LNP Formulation Responsibilities:

• Execute and optimize the formulation and characterization of lipid nanoparticles (LNPs) and targeted lipid nanoparticles (tLNPs) encapsulating nucleic acids for in vitro and in vivo studies, under minor guidance from senior formulation scientists.
• Implement Design of Experiment (DoE)-based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Support early-stage formulation development and downstream processing activities as needed, including cryoprotection, scale-up, and stability studies, and collaborate cross-functionally with internal teams to fulfill formulation requests.
• Maintain detailed records of formulation activities and results, and analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.

Scientist II - LNP Formulation Qualifications:

• 5+ years of biopharma industry experience with a Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline; OR
• 2+ years of industry experience with a Master's degree.
• 2+ years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• High proficiency in Microsoft Excel.
• Strong attention to detail, with a track record of producing reproducible data.
• Experience with statistical and data analysis software, such as JMP or Prism, is preferred.
• Prior experience with targeted LNP preparation (mAb, Fab, ScFv, or VHH-coated LNPs) and immune cell delivery is preferred.

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