iPSC, Senior Research Investigator

About us

BeOne is a global oncology company that is discovering and developing innovative treatments that are more affordable and accessible to cancer patients worldwide. With a broad portfolio, we are expediting development of our diverse pipeline of novel therapeutics through our internal capabilities and collaborations. We are committed to radically improving access to medicines for far more patients who need them. Our growing global team of more than 10,000 colleagues spans five continents, with administrative offices in Basel, Beijing, and Cambridge, U.S. To learn more about BeOne, please visit www.beonemedicines.com and follow us on LinkedIn and X (formerly known as Twitter).

BeOne continues to grow at a rapid pace with challenging and exciting opportunities for experienced professionals. When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

Job Description:

BeOne Medicines is seeking an innovative and driven Research Scientist to contribute to the development of our next-generation iPSC-derived cell therapy pipeline across oncology and immunology & inflammation (I&I) indications. The successful candidate will bring strong scientific judgment, hands-on research experience, and the ability to independently drive complex research activities from concept through execution.
In this role, you will apply expertise in areas such as iPSC biology, cell engineering, and immunological functional characterization to advance therapeutic programs. You will work closely with cross-functional teams to translate disease-specific therapeutic goals into actionable R&D plans, troubleshoot complex biological and technical challenges, and drive projects toward key milestones. Depending on experience and demonstrated capabilities, the role may provide opportunities to take on increasing project ownership and scientific leadership responsibilities.

Main Roles & Responsibilities

1. Strategic R&D & Experimental Design
a. Conceptualize, design, and optimize robust strategies for iPSC differentiation and lineage assessment.
b. Translate high-level therapeutic objectives into rigorous, hypothesis-driven experimental roadmaps aligned with corporate pipeline milestones.

2. Project Execution & Cross-Functional Collaboration
a. Drive project execution, including experimental planning, timeline management, data analysis, and coordination across multiple workstreams.
b.Collaborate effectively with cross-functional teams to ensure alignment of scientific objectives, priorities, and deliverables.
c. Synthesize complex datasets into clear, actionable presentations and technical reports for internal leadership, cross-functional teams, and external stakeholders.

3. Advanced Assay Development & Functional Profiling
a. Lead the design, optimization, and execution of comprehensive in vitro assays, including high-parameter multi-color flow cytometry, immune effector cytotoxicity, co-culture killing assays, and multiplex cytokine profiling.
b. Drive deep phenotypic and functional characterization of iPSC-derived cell products to support product and process development.
c. Develop and optimize fit-for-purpose analytical approaches to address program-specific scientific questions.

4. GxP Cleanroom Support
a. Provide support for GxP cleanroom activities as needed based on project requirements.

Qualification Required:

Requirements & Technical Skills

• Education & Experience: Ph.D. in Immunology, Stem Cell Biology, Molecular Biology, Cell Biology, or a related discipline (preferably with 2+ years of relevant industry or postdoctoral experience). Candidates with a Master’s degree and 4+ years of progressive industry experience with a proven track record of project ownership will also be considered.

• Technical Expertise:
o In-depth hands-on and theoretical expertise in cell therapy and immunotherapy principles.
o Proven capability in high-parameter flow cytometry, immunological functional assays (e.g., CAR-T or NK/T-cell cytotoxicity, intracellular cytokine staining, cytokine bead array), and primary/engineered immune cell co-cultures.
o With an understanding of GxP cleanroom operations, process development, or translational cell therapy manufacturing is highly advantageous.

• Core Competencies:
o Track record of independent research design, high-impact problem solving, and scientific publications or patent filings.
o Strong project management skills with the ability to balance scientific rigor against aggressive corporate timelines.

Working Conditions & Accountability
• Weekend Duty: Willingness to participate in rotating weekend schedules for critical cell culture tasks. Compensatory leave will be provided for weekend shifts.
• Work Environment: Agile, milestone-driven biotechnology laboratory environment requiring collaborative problem-solving, high scientific integrity, and proactive communication.

What We Offer To Our Valued Employees

• Market competitive compensation package including performance-based annual bonus scheme

• Company shares (generous welcome grant!)

• In-house and external learning and development opportunities

• Fantastic benefits program and keep improving!

• Plus you get to work with a dynamic team of collaborative, supportive, inclusive, and fun professionals whose mission is clear: Cancer has no borders and neither do we.

• Join us and Make momentum in your career!

BeOne Global Competencies

When we exhibit our values of Patients First, Collaborative Spirit, Bold Ingenuity and Driving Excellence, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.

• Fosters Teamwork
• Provides and Solicits Honest and Actionable Feedback
• Self-Awareness
• Acts Inclusively
• Demonstrates Initiative
• Entrepreneurial Mindset
• Continuous Learning
• Embraces Change
• Results-Oriented
• Analytical Thinking/Data Analysis
• Financial Excellence
• Communicates with Clarity

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