Senior Scientist II, Biomolecular Characterization
BigHat Biosciences
·Sep 1, 2026
- Salary
- $145k – $165k
- Location
- San Mateo, CA
- Type
- Full-time
- Department
- Education
- Seniority
- Senior
- Education
- PhD
- Source
- Pinpoint
Description
Senior Scientist II, Biomolecular Characterization
Department: Lab Science
Employment Type: Full Time
Location: San Mateo, CA
Description
The role: BigHat Biosciences is seeking an exceptional individual for a Senior Scientist I/II, Biomolecular Characterization* role to drive characterization of in vitro antibody-target binding behavior.
*At BigHat we believe in titles that are commensurate with skill set, relative organizational impact, and value contribution; more or less experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.
Key Responsibilities
- Individual contribution at the bench with strong cross-functional collaboration with scientists, ML/DS, and program teams.
- Develop, optimize, and implement high- and low-throughput state-of-the-art strategies to characterize the interactions between antibody and antigen using biolayer interferometry (BLI) and surface plasmon resonance (SPR).
- Design and perform epitope binning assays to cluster antibodies into functional families.
- Source, develop, and validate competitive binding/blocking assays to triage candidate antibodies.
- Collaborate closely with the BigHat science organization to accelerate hits from discovery through lead optimization and candidate nomination.
- Effectively synthesize and communicate results and research activity to key decision-makers and the broader BigHat team, as well as to external partners.
Skills Knowledge and Expertise
- M.Sc/Ph.D. in molecular or cell biology, immunology, or related fields.
- 5+ years of advanced, independent research experience in an industry setting, including substantial experience with the Octet BLI and/or Biacore platforms.
- Practical and theoretical fluency with using various BLI sensor types for the determination of antibody-antigen binding kinetics and epitope binning.
- Deep technical knowledge regarding chip chemistries and characteristics for SPR measurements.
- Experience measuring binding interactions with recombinant soluble, transmembrane, and cell based antigens and a variety of antibody formats.
- Experience managing teams or demonstrated mentorship of junior scientists strongly preferred.
- Ability to manage and prioritize requests from cross-functional stakeholders.
- Strong data analysis and interpretation skills.
- Exceptional written, verbal, and visual communication skills.
- Ability to educate and build consensus among diverse stakeholders regarding scientific direction.
- Experience with lab automation is a plus.
Total Rewards
The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.