US Medical Franchise Head, Hematology

Introduction to Role

At AstraZeneca, we turn ideas into life-changing medicines. Working here means being entrepreneurial, thinking big, and collaborating to make the impossible a reality. We are passionate about the potential of science to address the unmet needs of patients around the world and focus on areas where we believe we can meaningfully change the course of disease.

As the US Medical Franchise Head, Hematology, you will provide strategic and scientific leadership for the US Hematology Medical Affairs organization. You will be accountable for defining and delivering the US Medical strategy across the hematology franchise, translating emerging science and insights from the healthcare ecosystem into strategies that advance patient care and enhance the impact of our portfolio.

You will lead a high-performing organization spanning headquarters and field medical teams, partner closely with Global Medical, R&D, Commercial, Market Access, Real-World Evidence, Government Affairs, and Patient Advocacy, and serve as a senior medical voice for the hematology franchise in the US.

Accountabilities

• Set and lead the US Medical strategy for the Hematology franchise, ensuring alignment with US business priorities, Global Medical strategy, lifecycle plans, and evolving patient, provider, payer, and healthcare system needs.

• Deliver a coordinated US medical evidence generation strategy across the hematology portfolio, including late-phase and post-approval studies, real-world evidence, health outcomes research, externally sponsored research, and other evidence-generation activities developed to address clinically relevant evidence gaps.

• Lead the US Hematology Medical Affairs organization, including headquarters and field medical teams, crafting an environment characterized by scientific excellence, innovation, accountability, inclusion, collaboration, and high performance.

• Provide strategic oversight and leadership across the hematology portfolio, ensuring Medical strategies and plans support assets across different stages of the product lifecycle, from launch readiness and indications under development through lifecycle management and mature brands.

• Build organizational capability and a strong talent pipeline by establishing clear accountabilities, developing and retaining outstanding talent, strengthening succession plans, and encouraging continuous learning and improvement.

• Generate and translate actionable medical insights from healthcare professionals, scientific leaders, patients, payers, treatment centers, and other partners to advise US and Global Medical strategy, evidence-generation priorities, clinical development, and portfolio decisions.

• Lead strategic engagement with external scientific and medical leaders, including hematologists, oncologists, investigators, academic institutions, collaborative groups, medical societies, and other organizations crafting the future of hematology care.

• Advance the scientific exchange strategy for the franchise, ensuring field medical teams are equipped to engage credibly and stays in sync with external partners regarding evolving science, treatment paradigms, unmet needs, and the AstraZeneca hematology portfolio.

• Partner across functions and geographies, including R&D, Global Medical Affairs, Commercial, Market Access, Real-World Evidence, HEOR, Regulatory, Government Affairs, Corporate Affairs, and Patient Advocacy, to ensure a coordinated approach to advancing patient outcomes.

• Serve as a senior US Medical representative for Hematology in key governance forums, providing scientific and medical leadership to portfolio, investment, lifecycle, launch, and business development decisions.

• Identify emerging trends and innovations in hematology, including new therapeutic modalities, diagnostics, biomarkers, treatment pathways, and models of care, and translate these developments into implications for AstraZeneca's portfolio and Medical strategy.

• Champion compliant, ethical, and patient-centered Medical Affairs practices, ensuring activities meet applicable regulatory requirements, company policies, scientific standards, and expectations for medical governance.

Essential Skills/Experience

• Sophisticated scientific or clinical degree such as MBBS, MD, DO, PharmD, PhD, or equivalent medical education. Medical specialty training is strongly preferred.

• Significant experience in the pharmaceutical/biotechnology industry, including senior leadership experience within Medical Affairs and/or clinical development.

• Demonstrated expertise in hematology and/or hematologic oncology, with solid understanding of the US treatment landscape, evolving standards of care, clinical development, and healthcare environment.

• Validated experience developing and accomplishing portfolio- or franchise-level Medical strategies, ideally across multiple assets, indications, and stages of the product lifecycle.

• Demonstrated success leading leaders and multidisciplinary Medical Affairs organizations, including headquarters and field medical teams.

• Consistent track record in evidence generation, including the ability to translate scientific and clinical evidence gaps into coordinated evidence plans.

• Significant experience engaging external scientific authorities, investigators, academic institutions, medical societies, and other healthcare partners.

• Proven track record to influence and lead across sophisticated, highly matrixed organizations and to build positive relationships across Medical, R&D, Commercial, Market Access, and other functions.

• Outstanding scientific judgment, executive communication, critical thinking, and ability to make decisions in a rapidly evolving therapeutic environment.

Desirable Skills/Experience

• Deep expertise in one or more areas of hematology, including hematologic malignancies, rare blood disorders, or other relevant hematology disease areas.

• Experience supporting major US launches, indication expansions, and lifecycle management for hematology medicines.

• Experience designing or supervising Phase IIIb/IV, observational, registry, real-world evidence, health outcomes, and post-authorization research programs.

• Understanding of precision medicine, biomarkers, companion diagnostics, translational medicine, and emerging therapeutic modalities relevant to hematology.

• Experience incorporating patient-reported outcomes, health economics and outcomes research, quality improvement initiatives, and integrated care pathways into Medical strategies.

• Experience contributing to business development, external innovation, or scientific due diligence for potential assets or partnerships.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

Why AstraZeneca:

Here, scientific rigor meets bold technology to shape the future of healthcare at pace. You will lead in an environment that values kindness alongside ambition, where unconventional combinations of experts spark new ideas and translate them into products that change medical practice. With a rich, fast-advancing pipeline across multiple therapy areas and deep partnerships across development, evidence, and external experts, your work will directly improve how science reaches patients—while giving you room to experiment, learn, and scale innovations that endure.

The annual base pay for this position ranges from $283,386 to $425,080 Hourly and salaried non-exempt employees will also be paid overtime pay when working qualifying overtime hours. Base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience. In addition, our positions offer a short-term incentive bonus opportunity; eligibility to participate in our equity-based long-term incentive program (salaried roles), to receive a retirement contribution (hourly roles), and commission payment eligibility (sales roles). Benefits offered included a qualified retirement program [401(k) plan]; paid vacation and holidays; paid leaves; and, health benefits including medical, prescription drug, dental, and vision coverage in accordance with the terms and conditions of the applicable plans. Additional details of participation in these benefit plans will be provided if an employee receives an offer of employment. If hired, employee will be in an “at-will position” and the Company reserves the right to modify base pay (as well as any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.

Date Posted

11-Nov-2026

Closing Date

24-Nov-2026

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form.