Director, Global Supply Chain Excellence & Digital Enablement Lead

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Leads supply chain operational excellence and digital enablement to standardize best practices and improve execution performance across global teams. Owns a continuous improvement pipeline with disciplined intake, prioritization, delivery, and benefits tracking. Partners with IT / Analytics to simplify processes, automate workflows, and improve execution visibility through consistent metrics and reporting. Builds standard work, SOPs, and performance routines that reduce variability and improve plan-to-execution reliability. Ensures improvements are sustained through training, coaching, and controls.

Key Responsibilities

Operational Excellence & Standardization

• Standardize SOPs, templates, and performance routines, embed standard work and controls across teams
• Run CI pipeline (intake, prioritization, delivery, benefits tracking) and ensure sustainment mechanisms are in place
• Produce deliverables such as SOP / templates library, CI backlog, benefits tracker, and sustainment / control plans

Digital Enablement & Adoption

• Partner with IT / Analytics to automate workflows and improve dashboards / visibility aligned to operational needs
• Lead training, adoption tracking, and sustainment actions to embed new capabilities into daily routines
• Produce deliverables such as dashboard requirements, adoption metrics, training materials, and revised SOPs / standard work

Performance Management & Capability Building

• Establish KPI routines and escalation paths, ensure metrics drive action and consistent follow-up
• Build capability in structured problem solving and continuous improvement practices
• Produce deliverables such as KPI packs, tier-cadence agendas, and problem-solving toolkits

Required Qualifications

• BS+ (Supply Chain, Engineering, Business, or related)
• 12–15 years in supply chain excellence / CI roles scaling standards across teams / sites
• Demonstrated track record delivering measurable improvements and sustaining adoption

Preferred Qualifications

• Lean / Six Sigma certification (or equivalent) with applied results
• Familiarity with ERP / APS / WMS / TMS environments and process digitization
• Experience in pharmaceutical / biotech or other regulated operations (preferred)

Key Competencies

• Operational excellence, standard work / SOP governance, and KPI routines, benefits tracking and sustainment controls
• Digital enablement partnering (workflow automation, dashboards, reporting), adoption monitoring and corrective action
• Change management (impact assessment, stakeholder mapping, communications, training / SOP readiness, adoption measurement)
• Structured problem solving, root cause analysis, and continuous improvement pipeline management
• Cross-functional leadership, escalation, and executive-ready performance / risk communication

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands.  As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $194,000 - $237,000 per year.  We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].