- Salary
- €20k – €38k
- Location
- Mengeš, Slovenia
- Workplace
- Hybrid
- Type
- Full-time
- Department
- Education
- Experience
- 2+ years
- Closing date
- Today
- Source
- Workday
Description
Salary Range:
€20,300.00 - €37,700.00
Job Description Summary
#LI-HybridLocation: Mengeš, Slovenia
Role Purpose:
Our R&D unit in Mengeš is looking for a motivated scientist in field of Formulation development to join our unit and help us develop a diverse portfolio of biotherapeutic modalities.
As a Research Scientist you must demonstrate knowledge of pre-formulation/formulation and characterization to evaluate the developability of various biologics modalities covered by Novartis Biomedical Research and Development units, ranging from traditional antibodies to advanced biologics formats and mixed modalities. You will help shape the overall formulation strategy for large biomolecules before the project transition from research into early phase development and help funnel out unfavorable candidates with respect to formulation assessment.
We offer a stimulating work environment, ample opportunities for growth and development, and the chance to make a significant impact on the future of medicine. If you are a motivated and talented scientist with a passion for biomedical research, we invite you to apply and become a part of our dynamic team at Novartis.
Naša R&D enota v Mengšu išče motiviranega raziskovalca na področju razvoja formulacij, ki se bo pridružil naši enoti in nam pomagal razvijati raznolik portfelj bioterapevtikov.
Kot raziskovalec morate izkazovati znanje s področja predformulacijskih in formulacijskih študij ter karakterizacije za oceno razvojne primernosti različnih bioterapevtikov, ki jih obravnavajo enote Novartis Biomedical Research and Development, od tradicionalnih protiteles do naprednih bioloških formatov in kombiniranih modalitet. Pomagali boste oblikovati celovito strategijo formulacij za biološke kandidate pred prehodom projekta iz raziskovalne faze v zgodnji razvoj ter pomagali izločiti neustrezne kandidate z vidika formulacijske ocene.
Nudimo spodbudno delovno okolje, številne priložnosti za rast in razvoj ter možnost pomembnega vpliva na prihodnost medicine. Če ste motiviran in nadarjen raziskovalec s strastjo do biomedicinskih raziskav, vas vabimo, da se prijavite in postanete del naše dinamične ekipe v Novartisu.
Job Description
Key Responsibilities:
Perform preformulation assessment for monoconal antibodies, multispecific antibodies and other therapeutic proteins, including but not limited to solubility assessment and setup of formulation screening studies.
Perform biophysical characterization methods such as DSC/DSF, dynamic light scattering (DLS), UV-Vis, turbidity, sub visible particle assessment, viscosity and other techniques that are LC based method (SEC,HIC) for characterizing therapeutic proteins.
Utilize state-of-the art liquid handlers for compounding of formulations for large biotherapeutics to conduct stability studies on them
Conduct physicochemical analytics methods for characterization of various formats of biotherapeutics in screening, formulation andlead optimization stages
Operate and maintain instrumentations, perform data analysis and ELN documentation, and author method development and technical reports.
Work in a highly interdisciplinary and collaborative environment as part of global project teams and contribute to data analysis and interpretation, making technical presentations and report writing
Minimum Requirements - What you will bring to the role
MSc degree in biochemistry, biotechnology, chemistry or a related field; or BSc degree in biochemistry, biotechnology, chemistry or a related field with at least 2 year of relevant work experience
Good theoretical and practical laboratory experience in biophysical characterization methods such as DSC/DSF, DLS, UV-Vis, SEC, HIC
High learning ability to acquire expertise in new technologies and technical equipment
Excellent organizational skills with the ability to run multiple projects in parallel
Reliable and flexible team player, accustomed to sharing tasks and projects
Fluency in English (oral/written)
Desirable skills:
Experience in a neighboring discipline (Phys-Chem analytics)
Benefits & Rewards
At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
Expected Annual Base Salary Range for role: €20,300 to €37,700
The base salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.
In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters.
The rewards of being part of our team go far beyond base pay and incentives. We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and minimum 14 weeks paid parental leave.
Ključne odgovornosti:
Izvajanje predformulacijskih študij za monoklonska protitelesa, multispecifična protitelesa in druge terapevtske proteine, vključno, vendar ne omejeno na oceno topnosti in pripravo presejalnih formulacijskih študij.
Izvajanje biofizikalnih karakterizacijskih metod, kot so DSC/DSF, dinamično sipanje svetlobe (DLS), UV-Vis, motnost, ocena subvidnih delcev, viskoznost in druge tehnike, ki temeljijo na LC-metodah (SEC, HIC), za karakterizacijo terapevtskih proteinov.
Uporaba najsodobnejših avtomatiziranih sistemov za pipetiranje za pripravo formulacij bioterapevtikov za izvajanje študij stabilnosti.
Izvajanje fizikalno-kemijskih analiznih metod za karakterizacijo različnih formatov bioterapevtikov v fazah presejanja, razvoja formulacij in optimizacije vodilnih kandidatov.
Upravljanje in vzdrževanje instrumentacije, analiza podatkov in dokumentiranje v ELN ter priprava poročil o razvoju metod in tehničnih poročil.
Delo v visoko interdisciplinarnem in sodelovalnem okolju kot del globalnih projektnih ekip ter prispevanje k analizi in interpretaciji podatkov, pripravi tehničnih predstavitev in pisanju poročil.
Minimalne zahteve – kaj boste prispevali k vlogi
Univerzitetna izobrazba / magisterij (MSc) s področja biokemije, biotehnologije, kemije ali sorodnega področja; ali Visokošolska izobrazba (BSc) s področja biokemije, biotehnologije, kemije ali sorodnega področja ter najmanj 2 leti ustreznih delovnih izkušenj.
Dobro teoretično in praktično laboratorijsko znanje s področja biofizikalnih karakterizacijskih metod, kot so DSC/DSF, DLS, UV-Vis, SEC in HIC.
Visoka sposobnost učenja za pridobivanje strokovnega znanja o novih tehnologijah in tehnični opremi.
Odlične organizacijske sposobnosti ter zmožnost hkratnega izvajanja več projektov.
Zanesljiv in prilagodljiv timski sodelavec, vajen delitve nalog in projektov.
Tekoče znanje angleškega jezika (ustno/pisno).
Zaželena znanja in izkušnje:
Izkušnje na sorodnem področju (fizikalno-kemijske analize)
Koristi in nagrade
V Novartisu smo zavezani skupnemu preoblikovanju medicine – in nagrajevanju ljudi, ki jo uresničijo.
Pričakovana letna osnovna plača Razpon za delovno mesto: €20,300 do €37,700
Osnovna plača je določena glede na spolno nevtralne cilje, kot so relevantne veščine, kompetence in izkušnje v skladu s politiko plač Novartisa, ob vstopu v Novartis pa se redno pregleduje.
Poleg osnovne plače ste morda upravičeni do bonusa na podlagi uspešnosti, odvisno od določenih parametrov uspešnosti.
Nagrade, ki jih prinaša članstvo v naši ekipi, segajo daleč preko osnovne plače in spodbud. Ponujamo tudi različne konkurenčne ugodnosti v naravi, ki vam pomagajo uspevati osebno in poklicno, kot so zavarovalni načrti, pokojninski načrti, viri za dobro počutje in globalni programi priznanja. Poleg tega ponujamo prilagodljive in hibridne možnosti dela, kjer je mogoče, ter najmanj 14 tednov plačanega starševskega dopusta.
Skills Desired
Materials Science, Process Simulation
