JOB DESCRIPTION

We are looking for a Senior Research Technician to take ownership of a high-impact
project on non-genetic drug resistance in melanoma—and we want someone who treats
this as their own scientific mission. Your core task: develop and implement a
physiologically relevant 3D model that captures the real-time crosstalk between tumor
cells and the microenvironment, directly informing combination strategies to overcome
treatment failure. We need a hands-on expert in primary cell culture, multiplex assays,
and 3D scaffolds someone who troubleshoots independently, mentors effectively, and
bridges lab work with translational goals.

MAIN RESPONSIBILITIES

• Establish and optimize a 3D co-culture model integrating melanoma cells with stromal/immune components to mimic the tumor microenvironment.
• Perform drug sensitivity assays and longitudinal viability tests to monitor treatment response and acquired resistance.
• Conduct molecular analyses (RNA/protein extraction, qPCR, Western blotting, cytokine profiling) to characterize non-genetic adaptive changes.
• Carry out high-content imaging and quantitative microscopy to assess spatial interactions, invasion, and phenotypic plasticity within 3D constructs.
• Maintain detailed electronic lab records, analyze data with statistical rigor, and present results in team meetings.
• Train and supervise junior technicians/students, manage reagent inventory, and troubleshoot protocols proactively.
• Collaborate with bioinformaticians to integrate wet-lab data with omics datasets, feeding results into therapeutic strategy development.

QUALIFICATIONS AND EXPERIENCIE

• Master in Biomedicine or closely related field, with a focus on cancer research.
• Experience in tissue culture and data analysis
• Strong experience in molecular and cellular biology techniques (DNA and RNA isolation, RNA quantification, qPCR and immunofluoresence).
• Strong experience in cell culture, including the establishment of primary cultures.
• Experience in proteomics, particularly in O-Link analysis.
• Hands-on experience in clinical research environments.
• Basic knowledge of Rstudio.
• Good command of English, both written and spoken.
• International experience will be considered an asset.
• Experience in sòlid tumors tumors will be considered an asset.
• Proactive, motivated, and responsible individual with strong organizational skills and the ability to work autonomously

WHAT WE OFFER

• Indefinite contract (Science Law 14/2011) Full-time contract
• 20.000-25.000 gross salary
• Incorporation date: 1st of September
• Gross annual remuneration inherent to the square objected to this call, will be fixed based on the experience provided and the skills of the candidate, distributed in 12 payments.
• Flexible payment (childminding vouchers and meal voucher).
• 23 days holiday and 5 days for personal matters.
• Training capsules by the company.
• Be part of an excellent multidisciplinary research centre with the HRS4R badge.
• Location on the Can Ruti Campus, a first-class translational research environment in the Barcelona area, in a very stimulating scientific environment. The IGTP offers a supportive, friendly and collaborative ecosystem to promote professional development and help you achieve your research goals.

FOR MORE INFORMATION

https://www.germanstrias.org/en/research/cancer/23/oncology-translational-research-otr

HOW TO APPLY

Interested persons must attach to the application:

• Motivation letter explaining their interest in the position.
• Updated CV.
• Contact of 2-3 references.

Applications will be evaluated in accordance with the guiding principles and objectives of the supply systems, following the process described below:

Curricular evaluation: analysis of the curriculum vitae to assess aspects related to training, professional career and experience in positions related to the job position under selection.

Personal interview: once the résumé has been evaluated, the selected candidates will be called for a personal interview to verify and expand on the information detailed in the résumé and to evaluate aspects related to experience and professional skills.

Applications that do not meet the requirements, that are not included in the cases foreseen or that are not processed in accordance with the established procedure will not be considered in the selection process.

DEADLINE FOR APPLICATIONS

The call for applications will close on August 10th, 2026.