Senior Director, Leader and Org Enablement

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

Lead the execution of enterprise talent strategies that build leadership capability, enable AI-driven workforce transformation, strengthen succession pipelines, enhance performance ownership, and leverage people analytics to drive business outcomes. This role partners closely with HR Business Partners, HR CoE’s and business leaders to ensure talent practices align with organizational strategy and future workforce needs.

Primary Responsibilities

Leadership Development

• Design and implement enterprise leadership development strategy.
  • Build scalable leadership programs for new, mid-level, and senior leaders.
  • Assess leadership capability and identify development priorities.
  • Partner with HRBP and business leaders to strengthen leadership effectiveness and organizational capability.
  • Evaluate program impact and continuously improve learning experiences.
• AI People Transformation
  • Develop and execute people strategies that support AI adoption and workforce transformation.
  • Identify capability gaps created by AI and emerging technologies.
  • Partner across HR, IT, and business functions to redesign work, roles, and skills.
  • Drive change management initiatives that improve AI adoption and employee readiness.
  • Evaluate and introduce AI-enabled talent solutions and HR technologies.
  • Build AI-enabled workflows across talent management, leadership development, performance management and workforce planning by designing effective partnerships between people and AI agents.
• Talent & Succession Planning
  • Lead enterprise talent review and succession planning processes in partnership with HRBPs.
  • Develop succession pipelines for critical leadership and business-critical roles.
  • Create strategies to identify and accelerate high-potential talent.
  • Ensure talent decisions are data-driven, equitable, and aligned with future business needs.
  • Monitor organizational bench strength and succession readiness.
• Performance Ownership
  • Evolve the organization's performance management philosophy towards performance ownership, goals, continuous feedback and accountability.
  • Design processes that encourage meaningful performance conversations and coaching.
  • Partner with leaders to strengthen goal setting, performance differentiation, and development planning.
  • Improve manager capability in performance coaching and continuous feedback.
• People Analytics & Insights
  • Develop dashboards and metrics to evaluate talent health.
  • Translate workforce data into actionable insights for senior leadership.
  • Monitor trends in engagement, retention, mobility, succession, performance, and leadership effectiveness.
  • Use predictive analytics to inform workforce planning and talent investment decisions.
  • Present executive-ready insights and recommendations.

Qualifications

• Bachelor's degree required

• Senior Director:15+ years progressive HR/Talent Management experience, including enterprise-level strategy leadership and facilitation
• Experience leading leadership development, succession planning, talent management, or organizational development initiatives.
• Experience partnering with HRBPs and senior executives.
• Experience leading change and transformation initiatives.
• Experience using HR analytics to influence business decisions.
• Experience with AI-enabled HR technologies and digital transformation
• Role requires travel

Madrigal’s Total Rewards strategy is based on a biotech industry peer group comparator and is inclusive of base pay, bonus and equity. Our equity offers meaningful opportunity allowing our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.

All employees receive equity, which we believe reinforces our ownership culture. Base salary is determined by several factors including the candidate’s qualifications, skills, education, experience, business needs and market demands.  As of the date of this posting, a good faith estimate of the current pay scale for this position, applicable to all candidates, is $250,000 - $290,000 per year.  We comply with all applicable minimum wage laws.

All full-time employees receive equity, which reinforces our ownership culture and offers meaningful opportunity for our employees to share in the success they help create. By aligning individual and company performance, we empower employees to think like owners, giving them a stake in the organization.  

Full-time employees are also eligible for comprehensive benefits, including flexible paid time off, medical, dental, vision and life/disability insurance, and 401(k) offerings (i.e., traditional, Roth, and employer match) in accordance with applicable plans. We also offer additional voluntary benefits like supplemental life insurance, legal services, and other offerings. In addition, we offer mental health benefits through our Employee Assistance Program for employees and their family. The company also provides other benefits in accordance with applicable federal, state, and local laws. 

We are committed to providing reasonable accommodations for individuals with disabilities throughout the hiring process. If you need assistance, please contact [email protected]. 

Madrigal is an Equal Opportunity Employer. All employment is decided on the basis of qualifications, merit, and business need. Applicants will receive consideration for employment without regard to race, ethnicity, color, religion, sex gender identity, sexual orientation, national origin, age, disability, protected veteran or disabled status, or other characteristic protected by applicable federal, state, or local law. 

Unsolicited resumes from agencies should not be forwarded to Madrigal. Madrigal will not be responsible for any fees arising from the use of resumes through this source. Madrigal will only pay a fee to agencies if a formal agreement between Madrigal and the agency has been established. 

Applications are being accepted on an ongoing basis and can be submitted through our Madrigal Careers site. 

Please be aware that we have received reports of individuals misrepresenting themselves as Madrigal Pharmaceuticals’ Hiring Managers, seeking to engage with job candidates through fraudulent online advertisements or job posting sites. These unauthorized individuals are using Madrigal’s name and logo in an attempt to solicit up-front fees and obtain personal information from interested job candidates. Please know that Madrigal does not conduct interviews via text or in chat rooms; conduct interviews via Skype, RingCentral or solely via telephone; charge candidates an advance fee of any kind (e.g., fees for purchasing equipment); nor does it offer positions of employment without undergoing a thorough recruiting process.  

Please also note that any correspondence with regard to employment would come from an authorized madrigalpharma.com email address or from an email address from one of our trusted search firm partners. We are aware that incorrect/fraudulent email addresses, with Madrigal misspelled, have been utilized in these most recent fraud attempts. If you receive unsolicited employment offers from people claiming to work for or on behalf of Madrigal, we recommend that you: do not respond to their questions; do not open any attachments; and do not click on any hyperlinks. Any questions regarding the legitimacy of job-related contacts can be directed to [email protected].