Scientist

Position Overview

Contractor will independently provide support services to satisfy the overall operational objectives of the National Cancer Institute, Center for Cancer Research. The primary objective is to provide services and deliverables through performance of support services. Requires a Master's degree; a Ph.D. in Biology, Life Sciences, or a related discipline is required, along with a minimum of 2 years of experience in a laboratory environment.

 

Additional Qualifications

 

Certifications & Licenses

• Ph.D. in Biology, Life Sciences or related discipline

   

Field of Study

• Miscellaneous Biology

   

Software

• PowerPoint

• Microsoft Office Suite

• MS Word

• Excel

   

Skills

• Minimum of 2 years' experience in a laboratory environment

• Research experience in immunology and/or molecular biology

• Expertise in mouse handling procedures, including intraperitoneal/intravenous injections, tumor measurements, and dissections; immunologic studies including multi-parameter flow cytometric processing and data analysis, as well as in-vitro functional assays including cell culture, stimulation, proliferation, and cytokine production

• Expertise in molecular studies techniques including DNA/RNA extraction and quantification, gel electrophoresis, western blotting, PCR, and immunoprecipitation; helpful (though optional) experience in other techniques such as confocal microscopy

• Ability to learn new techniques and teach known techniques to others

• Knowledge of proper laboratory techniques, disposal methods, laboratory safety procedures, and universal precautions

• Ability to work independently on projects

• Excellent analytical, organizational, interpersonal, and time management skills

• Strong communication skills, both oral and written

• Proficiency in the use of computers and computer programs, including expertise in Microsoft Office Suite (MS Word, PowerPoint, Excel)

• Animal Handling: Mouse

   

Deliverables

• Work documents and products related to working with laboratory personnel in designing and performing experiments, data analysis and interpretation of results — Ad-Hoc

• Work documents and products related to initiating, designing, and developing new projects or assays that can enable the Center for Cancer Research/Rare Tumor Initiative, Dr. U. Rudloff's Laboratory to fulfill its responsibilities for advancing cancer research and development of cancer diagnostics, cancer drugs, and cancer vaccines — Ad-Hoc

• Work products and documents related to performing studies that result in technical reports and information to advance cancer research — Ad-Hoc

• Work products and documents related to working with the scientific staff to define key questions emerging from research projects in which experimental in vitro and in vivo analysis will contribute to elucidation of the impact of novel experimental therapeutics on immune cells, cancer cells, and tumors grown in mice in general, mechanisms of cell transformation, identification of molecular targets, and the development of biomarkers/biomarker signatures with potential to guide prevention, diagnosis, or treatment — Ad-Hoc

   

Statement of Work Details

• Conduct laboratory-based translational research with a focus on drug development for the treatment of cancer — 1

• Study cultured human and animal cell lines, some of which may be derived from cancer tissue, and analyze human and/or animal tissues with and without cancer — 2

• Perform a wide range of sophisticated genetic, biological, and biochemical assays, including, but not limited to, DNA transfection of cells, monolayer and anchorage-independent growth assays, immuno-precipitation assays, agarose gel electrophoresis, and in vivo and in vitro kinase assays — 3

• Perform confocal immune-confocal microscopy of cells — 4

• Supports the planning and execution of research experiments in the context of the laboratory's overall research program

• Perform studies that result in technical reports and information to advance cancer research

• Initiate, design, and develop new projects or assays that can enable the Center for Cancer Research/Laboratory of U. Rudloff, Rare Tumor Initiative, POB, NCI to fulfill its responsibilities for advancing cancer research and development of cancer diagnostics, cancer drugs, and cancer vaccines

• Serve as an authority on the tumor biology being studied and the assays being performed

• Interpret results of initial analysis to reveal conclusions and shortcomings; identify pitfalls in the original choice of methods or experimental direction; redirect the study to achieve improved results

• Identify the need for further investigations and/or propose a change in direction of work in light of accomplishments, findings, and current and future mission objectives

• Supports laboratory staff on research projects and techniques

• Work with the scientific staff to define key questions emerging from research projects in which experimental in vitro and in vivo analysis will contribute to elucidation of the impact of novel experimental therapeutics on immune cells, cancer cells, and tumors grown in mice in general, mechanisms of cell transformation, identification of molecular targets, and the development of biomarkers/biomarker signatures with potential to guide prevention, diagnosis, or treatment

• Collaborate with scientists and statisticians in NCI, NIH, and extramural research institutions as appropriate, to advance the research projects and elucidation of cancer-related data

• Collaborate with NIH/NCI expert staff to clarify needs and project objectives

• Maintains laboratory equipment and the training of others in their use

• Assists in maintaining adequate space and facilities for ongoing and projected research studies

• Evaluates, analyzes and interprets research data, communicates results and methods in reports, presentations, and manuscripts

• Attend seminars within the National Institutes of Health/Center for Cancer Research/Laboratory of U. Rudloff; pursue additional training where necessary; participate in discussions at meetings

• Make oral presentations at various conferences and seminars

• Prepare data sets, tables and figures for collaborative papers prepared for publication in peer-reviewed journals; assemble and write papers for first-author publication in peer-reviewed papers

• Participate in special committees, panels, and colloquia that meet to determine policy or plan activity in the field