Senior Research Associate, Solid Tumor CAR-T
Legend Biotech US
·Today
- Location
- Philadelphia, Pennsylvania, United States
- Department
- Solid Tumors
- Seniority
- Senior
- Source
- Greenhouse
Description
Legend Biotech is a global biotechnology company dedicated to treating and, one day, curing life-threatening diseases. Headquartered in Bridgewater, New Jersey, we are advancing the next generation of cell therapy through a portfolio of innovative technologies, including autologous, allogeneic, and in vivo cell therapy approaches. Our research spans chimeric antigen receptor T-cell (CAR-T), T-cell receptor (TCR-T), natural killer (NK) cell-based therapies, and other emerging platforms designed to transform the treatment of serious diseases. From our global network of research and development sites, we are committed to discovering and developing safe, effective, and cutting-edge therapies for patients worldwide.
Legend Biotech entered into a global collaboration agreement with Johnson & Johnson to jointly develop and commercialize CARVYKTI® (ciltacabtagene autoleucel; cilta-cel). Through this strategic partnership, we combine complementary expertise and capabilities to advance innovative immunotherapies for patients living with multiple myeloma.
Legend Biotech is seeking a Senior Research Associate, Solid Tumor CAR-T as part of the Research & Development team based in Philadelphia, PA.
Role Overview
We are seeking a highly motivated Senior Research Associate to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role will support our in vivo CAR-T platform, contributing to preclinical development from construct screening through animal model efficacy studies. You will work with the team to plan, execute, and troubleshoot experimental assays and laboratory methods, including cell-based functional and cytotoxicity assays, multi-color flow cytometry, ELISA and PCR-based assays, and viral vector packaging and titration.
The ideal candidate holds a BS or MS in Immunology, Immuno-Oncology, or a closely related discipline, with 0-5 years of experience in the biotech setting. You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.
Key Responsibilities
- Package and titer lentivirus
- Design and execute in vitro functional assays for safety and potency
- Perform construct screening for CAR design.
- Handling and engineering human and murine T cells.
- Engineering and maintaining various cancer cell lines for model development.
- Analyze and interpret data, troubleshooting, maintain detailed experimental records.
Requirements
- BS or MS.
- A scientist in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field.
- Candidates with experience in the biotech setting are strongly encouraged to apply.
- Primary human T cell isolation, activation, lentiviral transduction, and expansion are required.
- Familiarity with Incucyte, MSD, LDH release assay.
- Multicolor flow cytometry: panel design, data acquisition (e.g., Attune, Novocyte, Cytek Aurora), and analysis (FlowJo).
- Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot.
- High-throughput screening of drug candidates in the biotech setting.
- Experience in cell-based assay development and troubleshooting.
- Experience working with multiple immune cell types (T cell, B cell, myeloid) is a plus.
- Knowledge in specific tumor disease area.
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Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech.
Work Authorization & Employment Eligibility
Applicants must be authorized to work in the United States. As part of our commitment to maintaining a lawful workforce and ensuring compliance with federal employment regulations, we participate in the E-Verify program. If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify in accordance with applicable federal law. We are committed to providing a fair, transparent, and welcoming hiring experience for all candidates.
EEO Statement
It is the policy of Legend Biotech to provide equal employment opportunities without regard to actual or perceived race, color, creed, religion, national origin, ancestry, citizenship status, age, sex or gender (including pregnancy, childbirth, related medical conditions and lactation), gender identity or gender expression (including transgender status), sexual orientation, marital status, military service and veteran status, disability, genetic information, or any other protected characteristic under applicable federal, state or local laws or ordinances.
Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company.