Senior Principal Scientist Pharmacology

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Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Pharmacology

Job Category:

Scientific/Technology

All Job Posting Locations:

Beerse, Antwerp, Belgium

Job Description:

Position Title

Senior Principal Scientist Pharmacology

3Rs Portfolio Innovation and External Engagement

Location

Beerse, Antwerp, Belgium

 

Role Summary

The Sr. Principal Scientist & SIS Scientific Lead is a senior scientific role within Scientific & In Vivo Strategies (SIS), responsible for driving the identification and enablement of 3Rs innovation opportunities into the discovery and preclinical portfolio, including new approach methodologies (NAMs).

 

Operating within the enterprise 3Rs framework and aligned with Discovery, Product Development & Supply (DPDS), PSTS (Preclinical Safety and Translational Sciences), and SIS strategic priorities, this role brings deep NAMs expertise (i.e., refined in vivo, ex vivo, complex in vitro models (CIVMs)/microphysiological systems (MPS)/organoids, and/or in silico approaches) to enable portfolio‑relevant 3Rs innovation that strengthens discovery and preclinical assessment and improves preclinical-to-clinical translatability while advancing 3Rs objectives.  The individual will serve as a NAMs subject‑matter expert for SIS, DPDS, and Therapeutic Area stakeholders, ensuring that both internal and external NAM opportunities are identified and evaluated through portfolio‑relevant, translational, and regulatory‑aligned perspectives.

 

Primary Responsibilities:

NAMs Scientific Engagement and Portfolio Integration:

• Engage with fellow SIS Scientific Leads and  stakeholders to identify and evaluate ex vivo, in vitro, and in silico (in partnership with data science colleagues) NAM opportunities relevant to discovery and development programs

• Provide subject-matter expert-level guidance on applicability, strengths, limitations and readiness of NAMs within specific disease, modality and contexts of use

• Drive relevant incorporation of NAMs into program strategies, ensuring alignment with portfolio goals, scientific rigor and the broader enterprise 3Rs innovation framework

 

External NAMs Landscape and Regulatory Awareness:

• Maintain active awareness of the external NAMs landscape, including academic advances, emerging platforms and biotech innovations

• Evaluate external NAM developments in the context of scientific maturity, translational relevance, and evolving global regulatory perspectives (e.g., FDA, EMA, ICH, etc.)

• Translate external and regulatory signals into clear, balanced scientific insights to inform on current NAMs integration opportunities as well as to anticipate future state

 

Internal Capability Enablement:

• Liaison with fellow SIS Scientific Leads as well as internal functional and therapeutic area teams to assess existing NAM capabilities and gaps, relative to portfolio needs and regulatory expectations

• Inform prioritization of NAM development/evaluation and validation efforts based on scientific value-add, feasibility and anticipated regulatory acceptance

• Support development of internal guidance to enable confident and consistent application of NAMs

 

Scientific Collaboration and Communication:

• Serve as a scientific thought partner to drive project teams to consider 3Rs innovation/NAM-enabled approaches

• Contribute to internal scientific reviews, forums and working groups focused on 3Rs/NAMs innovation

• Support external scientific publications, presentations and internal communications that strengthen credibility and understanding of NAM-based strategies

 

Domestic and international travel may be required; up to 10%.

 

May perform other duties and matrix manage team members as assigned.

Education-Minimum Qualification

• Ph.D. in bioengineering, biomedical engineering, pharmacology, toxicology, systems biology or a related discipline with a concentration in Oncology

• 5+ years postdoctoral experience, preferably in a pharma or biotech setting, focused on NAMs-related platform development (i.e., CIVM/MPS, etc.) within oncology R&D

• Understanding of pharmaceutical R&D governance frameworks

• Excellent communication, facilitation, and leadership skills.

Required Skills

• Oncology therapeutic area expertise/experience
• Demonstrated expertise integrating models across the NAMs categorical landscape (i.e., combining ex vivo, in vitro/CIVM/MPS, in chemico, and/or in silico approaches) to enable advanced physio- and pathophysiological relevance at scale
• Demonstrated expertise applying human-relevant models in drug discovery and/or preclinical research contexts
• Track record of scientific innovation or publication in NAMs-relevant field
• Ability to critically assess emerging technologies/platforms within the context of pharma R&D needs and the external global regulatory landscape and clearly communicate implications to stakeholders
• Expertise in basic pharmacology concepts and experience in relevant data analysis best practices and software/tools
• Demonstrated leadership on drafting of scientific publications, internal reports and/or technical presentations
• People and research project management experience
• Proven effectiveness working with cross-functional scientific and data science stakeholders
• Demonstrated experience leading cross-functional initiatives in a matrixed environment.
• Experience interfacing with external technology developers and/or academic collaborators

Preferred Skills

• Experience managing and implementing organizational change
• General awareness of nonclinical safety and drug development concepts
• Familiarity with global regulatory agency considerations relevant to NAM acceptance

 

 

Required Skills:

 

 

Preferred Skills:

Clinical Data Management, Data Savvy, Drug Discovery Development, Innovation, Leadership, Pharmacodynamics, Pharmacology, Pharmacometrics, Pharmacovigilance, Product Lifecycle Management (PLM), Product Management, Research Documents, Risk Management, Scientific Research, Tactical Planning, Technical Credibility

  

 

The anticipated base pay range for this position is:

€96 000,00 - €165 025,00

 

 

Benefits:

In addition to base pay, we offer the following benefits*: an annual bonus with set target (% of pay) depending on pay grade / location, where the actual amount is based on the employees’ and companies’ performance of the previous calendar year, or sales commissions. Moreover, we offer vacation days, parental leave for a minimum of 12 weeks, bereavement leave, caregiver leave, volunteer leave, well-being reimbursement, programs for financial, physical and mental health. We also offer service anniversary and recognition awards, and subject to the terms of their respective plans, employees - and in some location’s eligible dependents - can participate in several insurance plans. For more information, visit Employee benefits | Supporting well-being & career growth | Johnson & Johnson Careers.

 

*This is for informative purposes only. Amounts and actual benefits may vary by location and are subject to change.

 

 

Additional information:

96 000,00 - 191 600,00 EUR Annual