Real World Evidence Associate Director

Job Description

General Summary:

The RWE Associate Director is an integral member of the RWE team who leverages expertise in epidemiology and real world data to develop fit-for-purpose observational research, and to inform internal and external stakeholders on natural history (NH) of disease and real world outcomes within their assigned therapeutic area. The RWE Associate Director works cross-functionally to support the execution of observational research across the portfolio.

Key Duties and Responsibilities:

Independently lead focused/targeted research of epidemiology of specific disease areas, including NH of disease for business development and early development indications

Lead data sourcing strategy for early development and early clinical indications to support NH of disease needed for regulators, payers, and clinicians

Lead and execute evaluation of available registries and other data sources related to NH and evidence to support clinical endpoints and inclusion/exclusion criteria

Determine potential use of RWE historical control within clinical development program and feasibility of obtaining data required for historical control

Lead execution of approved research tactics within assigned indications

Develop draft protocol concept and related materials for review and approval by internal scientific review boards

Working closely with stakeholders, align RWE research study tactics with functional and disease program goals

Contribute to development of performance metrics and dashboards for RWE projects

Represent RWE on relevant GMDA Sub-Teams, Program Teams, or Disease Strategy Teams where studies related to RWE are discussed

Represent RWE on cross-functional collaborations and working groups for pipeline product(s)

Utilize strong oral communications skills and understanding of Vertex strategies to promote and translate RWD/RWE methods and activities across the company

Support and facilitate external research collaborations with key academic partners, consortia, and data vendors

Support the development of cross-functional evidence generation planning

Provide leadership and mentorship within RWE

Contribute to company publications strategy via development of conference abstracts, presentations, peer-reviewed manuscripts based on the findings of RWE studies

Knowledge and Skills:

Applied knowledge of relevant RWE regulatory agency guidance and position papers and the opportunities to use RWE to inform regulatory decision making

Demonstrated ability to design and execute observational research

Strong and clear interpersonal communication, presentation, and study management skills

Ability to take detailed observational study results and communicate them in a clear, non- technical manner to internal cross-functional teams, using language that resonates with the teams, while maintaining the integrity of key findings

Ability to work collaboratively in a constantly changing, diverse, and matrix environment

Education and Experience:

PhD (preferred), or MS/MPH in epidemiology, biostatistics, health economics and outcomes research, or similar required

Formal graduate training in Epidemiology/Health Services Research required

Minimum 5 years of experience working in observational research within the life sciences industry or relevant academic, government, or consulting environment

Minimum 3 years of experience working in RWE and/or Epidemiology at a biopharmaceutical company

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

$174,400 - $261,600

Disclosure Statement:

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as: 
1.    Hybrid: work remotely up to two days per week; or select
2.    On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. 

#LI-Hybrid
 

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]