Principal Scientist, Medicinal Chemistry

PsiThera is seeking a talented and creative medicinal chemist with a strong track record of advancing peptide therapeutics and small molecule drug discovery projects from initial hits through to development candidate selection to join our dynamic, multidisciplinary team.  Our science and our team are focused on combining medicinal chemistry with our cutting-edge computational platform to rapidly identify and optimize molecules into innovative medicines for patients. 

We are looking for a self-motivated individual who thrives in a fast-paced, highly collaborative environment that integrates computational and experimental data to drive our programs to the clinic. The ideal candidate will have direct experience optimizing and advancing novel peptide therapeutics into clinical development, integrating a deep knowledge of synthetic and medicinal chemistry with in silico drug discovery methods to perform multiparameter optimization, including ADME/PK considerations, and rapidly advance programs from hit identification to lead selection to development candidate nomination. A successful candidate will have a deep knowledge in design and synthesis of peptides and peptidomimetics with enhanced potency, stability, and pharmacokinetic properties, strong synthetic chemistry skills, expertise in creative and practical small molecule design, experience guiding teams of CRO chemists and excellent communication skills.  

This individual will join our growing medicinal chemistry team and collaborate closely across functions including computational chemistry, biophysics, structural biology, and biology teams to provide actionable insights and strategic guidance.