- Location
- Waltham, MA · Waltham, Massachusetts, United States
- Department
- 4000GL - Medical Affairs
- Seniority
- Director
- Education
- PhD
- Visa
- Not sponsored
- Source
- Greenhouse
Description
Company Overview:
Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.
Role Summary:
The Global Medical Director, Medical Affairs serves as a strategic Global Medical Affairs Lead for Dyne’s programs, with responsibility for developing and executing integrated global medical plans that advance scientific understanding, evidence generation, external engagement, and launch readiness. This role represents Global Medical Affairs on highly visible cross-functional teams, including Program Teams, Clinical Development sub-teams, evidence generation forums, launch readiness workstreams, and future Brand Teams. This individual translates clinical and scientific insights into actionable medical strategies, supports congress, symposia, advisory board, publication, medical education, and evidence generation activities, and helps strengthen Dyne’s external scientific presence with healthcare professionals, key opinion leaders, payers, patient communities, and other stakeholders.
The Global Medical Director partners closely with Clinical Development, Clinical Operations, Regulatory Affairs, Scientific and Medical Communications, Value and Access, Commercial, Patient Advocacy, regional medical teams, and external experts to ensure medical plans are aligned with corporate, program, product, and regional priorities. The role also supports trial site engagement, patient journey and diagnostic pathway work, Target Product Profile development, payer and access planning, data gap assessment, insight generation, and medical input for partnered assets, as needed.
This position is based in Waltham, MA
Primary Responsibilities Include:
- Serve as the Global Medical Affairs representative and strategic medical lead on cross-functional teams supporting assigned neuromuscular disease programs
- Develop and execute integrated global medical plans aligned with corporate, program, product, evidence generation, and launch readiness priorities
- Act as a medical and scientific subject matter expert on Dyne’s FORCE platform, oligonucleotide and other relevant therapeutic modalities, and the scientific, clinical, diagnostic, and treatment landscape for assigned neuromuscular programs
- Maintain deep knowledge of scientific literature, clinical data, competitive intelligence, diagnostic pathways, treatment landscapes, patient journeys, and unmet needs for assigned programs
- Lead or support global KOL, payer, investigator, and external expert engagement strategies, including landscape mapping, engagement planning, insight gathering, synthesis, and reporting
- Partner with Clinical Development, Clinical Operations, Regulatory Affairs, Biometrics, Translational Medicine, and Program Leadership to support clinical trial planning, site engagement, data interpretation, and medical input into program strategy
- Identify medical evidence gaps and support development of evidence generation strategies, including real-world evidence, investigator-sponsored research areas of interest, post hoc analyses, natural history, registry, and other medical research initiatives
- Collaborate with Scientific and Medical Communications to support publication strategy, congress planning, symposia, medical education, abstracts, posters, presentations, field medical resources, and other scientific communications
- Partner with Value and Access, Commercial, New Product Planning, Patient Advocacy, and regional medical teams to inform TPP development, patient identification efforts, patient journey mapping, payer engagement plans, and launch readiness activities
- Ensure regional and field medical teams have the scientific context, resources, and aligned messaging needed to engage external stakeholders compliantly and effectively
- Translate external insights and emerging data into clear recommendations that inform global medical strategy, lifecycle planning, and cross-functional decision-making
- Support advisory boards, expert panels, congress activities, medical education programs, and other external engagements in accordance with Dyne policies and applicable regulations
- Contribute medical input to internal and external materials, as appropriate, ensuring scientific accuracy, consistency, and compliance
- Support partnered assets and business development activities, as needed, by providing medical affairs perspective and scientific insight
- Model integrity, accountability, collaboration, scientific excellence, and compliance in all internal and external interactions
Education and Skills Requirements:
- Advanced scientific or clinical degree required; MD, PhD, PharmD, or equivalent doctoral degree preferred
- 10+ years of relevant experience with 6+ in industry years of relevant experience in Medical Affairs, Clinical Development, Scientific Communications, or related roles within the pharmaceutical or biotechnology industry
- Experience in rare disease required; neuromuscular disease, genetic medicines, oligonucleotide therapeutics, ASOs, or related therapeutic areas strongly preferred
- Demonstrated ability to develop and execute medical strategies, global medical plans, evidence generation plans, KOL engagement strategies, congress plans, and publication or medical education activities
- Strong scientific acumen with the ability to interpret clinical, nonclinical, biomarker, real-world, and competitive data and translate insights into clear medical recommendations
- Experience working effectively on cross-functional asset, program, launch readiness, or brand teams in a matrixed organization
- Proven ability to build credible relationships with KOLs, healthcare professionals, investigators, payers, patient advocacy partners, and other external stakeholders
- Excellent written, verbal, and presentation skills with the ability to communicate complex scientific and medical information clearly to internal and external audiences
- Strong collaboration, influencing, prioritization, and problem-solving skills, with the ability to drive alignment and execution without direct authority
- Ability to operate with urgency, sound judgment, accountability, and flexibility in a fast-paced, growing biotechnology company
- Working knowledge of applicable medical affairs, compliance, regulatory, and scientific exchange standards
- Willingness to travel as needed for congresses, advisory boards, investigator or site engagement, external expert meetings, and internal meetings
- Positive team member who embodies Dyne’s core values and demonstrates strong commitment to patients, scientific integrity, and compliance
- Candidates must be authorized to work in the United States
#LI-Onsite
The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills.
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.
