Bioinformatics Scientist

Job Family:

Travel Required:

Clearance Required:

What You Will Do:
We are looking for a Bioinformatics Scientist to provide bioinformatics and data science support to advance NIEHS’s operational and research objectives. This role requires expertise in statistical genomics, machine learning, and scalable analysis and integration of high-dimensional omics data, applying AI-driven methods to generate biologically meaningful insights.  This is a full-time, on-site opportunity in Research Triangle Park, NC.  

• Generate and optimize programs, scripts, and algorithms for analyzing large-scale biological datasets.

• Perform computational analysis, interpret results, and produce scientific reports and data visualizations.

• Apply machine learning approaches to analyze and integrate large-scale multi-omic datasets to identify biological insights.

• Collaborate with scientists to design computational experiments, analyze data, and develop analytical pipelines.

• Conduct Next Generation Sequencing (NGS) data analysis including RNA-Seq, ChIP-Seq, and related genomic data.

• Perform genome-wide association studies, single-cell RNA sequencing, and multi-omics integration.

• Develop and maintain bioinformatics infrastructure, workflows, and reproducible analytical pipelines.

• Provide statistical support and develop novel analytical methodologies for complex biological data.

• Prepare reports, publications, and presentations for scientific meetings and external audiences.

• Maintain detailed documentation, lab notebooks, and analytical records; present results in lab meetings.

• Train staff and researchers on bioinformatics tools, pipelines, and computational methods.

• Collaborate across interdisciplinary teams and contribute to experimental design and research strategy.

• Evaluate emerging tools, techniques, and literature to improve analytical capabilities and research outcomes.

What You Will Need:

• Master’s degree in Bioinformatics, Computational Biology, Data Science, Biostatistics, Computer Science, or a related quantitative field.

• A minimum of ONE (1) year of experience in bioinformatics, data science, or related field.

• Demonstrated experience in machine learning, artificial intelligence, or advanced statistical modeling applied to biological data.

• Experience working with large-scale biological datasets (e.g., genomics, transcriptomics, proteomics, or multi-omics data).

• Proficiency in programming languages such as R, Python, MATLAB, Java, or similar.

• Experience with Linux/Unix environments, scripting (Bash, PERL), and version control systems (Git).

• Knowledge of workflow management systems and containerization tools (Docker, Singularity, Apptainer).

• Strong analytical, problem-solving, and data visualization skills.

• Ability to work independently and collaboratively in a multidisciplinary research environment.

• Strong written and verbal communication skills to present technical findings. Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

• Must be able to obtain and maintain a Federal or DoD "public trust"; candidates must obtain approved adjudication of their public trust prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred

What Would Be Nice To Have:

• Ph.D. in Bioinformatics, Biostatistics, Computational Biology, or related field.

• Experience with cloud platforms and high-performance computing (HPC) environments.

• Experience developing analytical pipelines for single-cell and multi-omics data integration.

• Familiarity with reproducible research practices and scientific workflow automation.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at [email protected]. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or [email protected].  Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse.  Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

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