Scientist 3 - Bioconjugation and Delivery

The Bioconjugation and Delivery group within Protein Sciences is at the forefront of therapeutic design, generating molecules with unique mechanisms of action. In this hands-on, laboratory-based role, you will learn and apply advanced bioconjugation techniques with precise analytical characterization to advance the next wave of antibody oligonucleotide conjugates and novel delivery strategies.

The Opportunity

• Design, optimize, and execute bioconjugation of proteins using chemical and enzymatic methods.

• Develop and implement purification protocols for bioconjugates using standard protein purification techniques.

• Perform analytical characterization of reaction mixtures and purified conjugates using chromatographic techniques (e.g., SEC, HIC, IEX), SDS-PAGE, colorimetric assays, and mass spectrometry (1D/2D LC-MS).

• Interpret experimental findings, report data clearly, and present results to cross-functional scientific teams.

• Manage inventory and sample tracking for completed conjugates and starting materials using digital management systems.

• Collaborate with multi-disciplinary scientific teams to advance innovative therapeutic modalities through the drug discovery pipeline.

Who You Are

You are a curious, collaborative, and early-career scientist eager to contribute to groundbreaking drug discovery and advance therapeutic modalities.

• Master’s degree or PhD in Chemistry, Biochemistry, Chemical Biology, Biophysics, Biomedical Engineering, or a related scientific discipline, combined with 3-5 years relevant research or industry experience.

• Practical experience or foundational understanding of protein purification and analytical characterization techniques (such as FPLC, HPLC, or LC-MS).

• Knowledge of or hands-on experience with oligonucleotides and/or antibody oligonucleotide conjugate generation.

• Strong communication, collaborative mindset, and interpersonal skills to thrive in an interdisciplinary environment.

Together, we’ll advance along the whole patient journey with the aspiration to prevent, stop and cure diseases.

Relocation benefits are not available for this posting.

This position is located in South San Francisco and is an on-site laboratory research position.

The expected salary range for this position based on the primary location of California is $103,400.00 - 192,000.00 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance.  This position also qualifies for the benefits detailed at the link provided below. 

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.