Senior Scientist

Job Family:

Scientist

Travel Required:

None

Clearance Required:

Ability to Obtain Public Trust

What You Will Do:

We are looking for a Senior Scientist to support the National Institute on Aging (NIA) research program through advanced synthetic chemistry, analytical chemistry, and laboratory operations support. This is a full-time position located in Baltimore, MD.

• Design efficient total organic synthesis schemes for oxylipins, endocannabinoids, SPMs, stable analogs, and other endogenous lipid mediators.

• Prepare, purify, isolate, and characterize compounds from synthesis or cell extracts using flash chromatography, HPLC, LCMS, MS/MS, UV-Vis, and NMR.

• Lead high-priority research projects, develop new procedures and techniques, and advance scientific discoveries focused on novel research treatments.

• Examine biochemical pathways, enzymatic transformations, biochemical stability, and compound properties to identify and evaluate endogenous mediator structures.

• Apply enzymatic, biogenic, and enantioselective synthesis approaches, including stability testing and full spectral characterization.

• Perform site-directed peptide and protein chemical modifications; design and screen neo-epitopes as antigens for monoclonal and polyclonal antibody development.

• Support synthetic and analytical chemistry for complex lipo-particles, including lipoproteins, and conduct liquid chromatography and mass spectrometry analyses using ion trap and triple quadrupole techniques.

• Maintain, calibrate, troubleshoot, and oversee laboratory instrumentation, equipment, inspections, infrastructure maintenance, evaluations, and routine maintenance activities.

• Train laboratory personnel on instrumentation, laboratory techniques, and synthetic chemistry methodologies; provide on-site technical guidance to staff, fellows, post-doctoral researchers, technicians, and trainees.

• Maintain accurate electronic laboratory notebooks, research documentation, and data management for processed compounds and research projects.

• Coordinate with junior staff to improve research protocols and develop safe handling procedures for laboratory chemicals and equipment.

• Support laboratory resource planning, future allocation reviews, procurement quotes, and supply, chemical, and equipment purchasing activities.

• Search scientific literature for relevant methods and techniques; analyze, interpret, and communicate findings through reports, presentations, manuscripts, meetings, conferences, and symposia.

• Co-author peer-reviewed manuscripts and present project updates and research findings to laboratory members and leadership.

• Attend meetings and conference calls, provide regular project status updates, and adhere to all safety, security, regulatory, and confidentiality requirements.

• Incumbent capture; no other candidates were considered because the incumbent was identified and meets the customer-provided labor category requirements.

What You Will Need:

• Master's degree in Biology, Chemistry, or a related scientific discipline.

• Minimum TEN (10) years of experience supporting biological, biochemical, synthetic chemistry, or related laboratory research programs.

• Background conducting organic synthesis and compound purification activities.

• Proficiency utilizing analytical techniques including HPLC, LCMS, MS/MS, UV-Vis, and NMR.

• Demonstrated ability to maintain laboratory records, research documentation, and electronic laboratory notebooks.

• Skilled in analyzing and interpreting scientific data and preparing technical reports.

• Ability to train laboratory personnel and provide technical guidance.

• Proficiency with Microsoft Office Suite, including Word, Excel, and PowerPoint.

• Ability to work onsite in a laboratory environment and comply with established safety requirements.

• Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

• Incumbent capture – no other candidates were considered due to an identified incumbent who meets the labor category requirements provided by the customer

What Would Be Nice To Have:

• Advanced background in synthetic organic chemistry.

• Knowledge of endogenous lipid mediator synthesis and characterization.

• Familiarity with oxylipins, endocannabinoids, lipid-peptide adducts, and specialized pro-resolving mediators (SPMs).

• Strong verbal and written communication skills.

• Hands-on use of enzymatic synthesis techniques, including lipoxygenase enzyme applications.

• Exposure to laboratory operations, resource planning, and equipment lifecycle management.

• Track record authoring peer-reviewed scientific publications.

• Ability to present research findings at national scientific meetings and conferences.

• Prior support for federal research programs, academic laboratories, or biomedical research environments.

The annual salary range for this position is $149,000.00-$248,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at [email protected]. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or [email protected].  Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse.  Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact [email protected]. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.